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Assessing the biocompatibility and stability of CeO2 nanoparticle conjugates with azacrowns for use as radiopharmaceuticalsстатья
- Авторы: Khabirova Sofia, Menshikov-Tonyan Mikhail, Aleshin Gleb, Prikhodko Anastasia, Kozlov Daniil, Anokhin Evgeny, Babeshkin Konstantin, Titchenko Nikolay, Zubenko Anastasia, Shchukina Anna, Fedorov Yuri, Kalmykov Stepan
- Журнал: RSC Medicinal Chemistry
- Год издания: 2024
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- DOI: 10.1039/D4MD00515E
- Аннотация: The application of nanoparticles is promising for the purposes of nuclear medicine due to the possibilities of using them as vectors and transporters of radionuclides. In this study, we have successfully synthesised conjugates of CeO2 nanoparticles and azacrown ligands. Then, the radiolabelling conditions with radionuclides 65Zn, 44Sc and 207Bi were selected and the kinetic stability of the complexes in biologically significant media was evaluated. Optimum conditions for CeO2-APTES-L and CeO2-APTES-DOTA labelling were found: 0.1 g l−1 conjugate and 10−9 M metal cations at 90 °C for complexes with [65Zn]Zn2+, [44Sc]Sc3+ and [207Bi]Bi3+. CeO2-APTES-L-44Sc (radiochemical purity more than 90%) was stable in fetal bovine serum. The obtained results enabled us to choose the most promising complex for biomedical applications for carrying out in vitro and in vivo biodistribution research. Nanoceria and its derivative showed no obvious toxicity to human endothelial cells EA.hy926. Then, the in vivo stability of the studied scandium complex was demonstrated. Taken together, our studies show that functionalised cerium oxide nanoparticles lead to stable radiolabelled nanosystems that may be used for targeted drug delivery, diagnosis and treatment of oncological diseases.
- Добавил в систему: Меньшиков-Тонян Михаил Андреевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Экспертное заключение ИНЭОС | инэос_экспертное_заключение.pdf | 243,7 КБ | 5 декабря 2024 [annbakhareva] | |
| 2. | Полный текст | d4md00515e.pdf | 2,4 МБ | 27 сентября 2024 [Sofia_] | |
| 3. | Заключение_о_возможности_открытого_опубликования.pdf | Заключение_о_возможности_открытого_опубликования.pdf | 236,5 КБ | 27 сентября 2024 [Sofia_] |