ИСТИНА

The aim of this study was to establish correlations between non-invasively measured parame-ters of capillary blood flow, skin perfusion and endothelial function with microrheological pa-rameters measured in blood samples in vitro. Quantitative assessment of capillary blood flow parameters in vivo was performed using opti-cal capillaroscopy [1], perfusion and endothelial function parameters were measured in vivo us-ing laser Doppler flowmetry and occlusion plethysmography. To characterize the microrheologi-cal properties of erythrocytes and platelets in vitro, the methods of laser aggregometry and dif-fractometry, optical trapping of erythrocytes, and light scattering turbidimetry were used [2-3]. The study involved healthy volunteers and patients with cardiovascular diseases (CVD): arterial hypertension, chronic heart failure, atrial fibrillation, coronary heart disease. The results demonstrate the presence of statistically significant correlations between hem-orheological parameters measured in vitro and in vivo. For example, there is a negative correla-tion between the index of aggregation of erythrocytes and platelets with the capillary blood flow velocity. The presence of CVD leads to increased aggregation, reduced deformability of erythro-cytes, as well as impaired perfusion, endothelial function and deterioration of terminal microcir-culation. Using non-invasive methods, it is possible not only to determine the parameters of blood flow, but also to judge the microrheological parameters of the blood, and vice versa. These advantages are important for a comprehensive assessment of the hemorheological status of patients using the personalized medicine approach and will help practicing physicians adjust the treatment of CVD. This work was supported by the Russian Science Foundation (Grant № 25-15-00172).