The Divergence and Natural Selection of Autocatalytic Primordial Metabolic Systemsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 апреля 2015 г.
Аннотация:The diversity of the central metabolism of modern organisms is caused by the
existence of a few metabolic modules, combination of which produces multiple metabolic
pathways. This paper analyzes biomimetically reconstructed coupled autocatalytic cycles as
the basis of ancestral metabolic systems. The mechanism for natural selection and evolution
in autocatalytic chemical systems may be affected by natural homeostatic parameters such as
ambient chemical potentials, temperature, and pressure. Competition between separate parts
of an autocatalytic network with positive-plus-negative feedback resulted in the formation of
primordial autotrophic, mixotrophic, and heterotrophic metabolic systems. This work examined
the last common ancestor of a set of coupled metabolic cycles in a population of
protocells. Physical-chemical properties of these cycles determined the main principles of
natural selection for the ancestral Bacteria and Archaea taxa.