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Aggregation polymorphism of photoactivatable Pt(IV) prodrugs as a strategy for the design of theranostic nanomaterialsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Bykusov Vladislav, Kuzmichev Ilya, Stepanov Maxim E., Bunin Dmitry, Luponosov Yuriy N., Isaeva Yulia, Trul Askold A., Akasov Roman, Egorova Tatiana, Erofeev Alexander, Kuanaeva Regina, Maksimova Yulia, Abakumov Maxim Artemovich, Nikitin Aleksey A., Kuzmin Vladimir A., Egorov Anton E., Burtsev Ivan, Rodin Igor, Vokuev Mikhail F., Beloglazkina Elena K., Krasnovskaya Olga O.
- Журнал: Dalton Transactions
- Год издания: 2026
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- DOI: 10.1039/d5dt02973b
- Аннотация: The design of multifunctional theranostic nanomaterials, including the application of J-aggregates as photothermal (PTT) and photodynamic (PDT) therapy agents, is in high demand. Here, we report J-aggregates based on two photoactivatable Pt(IV) prodrugs NO2-Pt and C6F5-Pt with acceptor BODIPYs in the axial position with the A-A-D structure, capable of pho-toinduced cisplatin release in addition to PDT and PTT activity. Fluorophores showed aggregation polymorphism de-pending on the solvent used; non-fluorescent CT-coupled J-aggregates with a small bathochromic shift and fluorescent slip-stacked J-aggregates with a high bathochromic shift were isolated and characterized. These data represent an im-portant study of the influence of fluorophore structure on photophysical properties of J-aggregates and demonstrate the possibility of designing theranostic agents based on photoactivated Pt(IV) prodrugs.
- Добавил в систему: Красновская Ольга Олеговна
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