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1,8-Naphthalimide-Based Fluorescent Bisphosphonates: Molecular Design, Spectral-Luminescent Properties, and Osteotropic Targeted Delivery Systemsстатья
Дата последнего поиска статьи во внешних источниках: 1 апреля 2026 г.
- Авторы: Yuriev D.Yu, Barabanshchikov I.V., Strukova V.A., Tkachenko S.V., Pakhomov A.A., Deev S.M., Akimov M.G., Ternovaya N.D., Sherstyanykh G.D., Sazonova V.A., Kalinkina V.A., Ulasevich S.A., Oshchepkov M.S.
- Журнал: Russian Journal of Bioorganic Chemistry
- Том: 52
- Номер: 2
- Год издания: 2026
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1
- Последняя страница: 20
- Номер статьи: 54
- DOI: 10.1134/s1068162025605105
- Аннотация: Objective: Pathological calcification and bone-metastatic cancers represent significant diagnostic and therapeutic challenges. This study aims to develop a novel theranostic platform based on 1,8-naphthalimide-derived fluorescent bisphosphonates for the selective detection of hydroxyapatite deposits and the creation of effective osteotropic drug delivery systems for bone cancer treatment. Methods: A series of new fluorescent bisphosphonates with systematically varied substituents were synthesized. Their photophysical properties were thoroughly characterized using spectrophotometric and spectrofluorimetric analysis in aqueous and viscous media. The lead compound, a 4-(2-hydroxyethylthio)-substituted derivative, was covalently conjugated to PLGA copolymer via Steglich esterification. PLGA nanoparticles were subsequently fabricated from the conjugate using an ultrasonic method. Internalization and distribution were visualized using fluorescence microscopy on Saos-2 and C2C12 cell lines. Results and Discussion: The synthesized bisphosphonates demonstrated excellent spectral-luminescent characteristics in water, with high quantum yields and viscosity-sensitive emission, confirming their suitability as microenvironment sensors. Cytotoxicity analysis confirmed the low toxicity of the lead compounds and of the nanoparticles on the Saos-2 cell line. The possibility of fluorescence imaging combined with the therapeutic effect of drug loading will further allow these nanoparticles to be considered a promising platform for simultaneous visualization and targeted therapy of bone cancer. Conclusions: We have developed and validated a versatile platform comprising novel fluorescent bisphosphonates and their functionalized PLGA nanocarriers. This study provides a robust foundation for the next generation of targeted theranostic agents for bone pathologies.
- Добавил в систему: Юрьев Данил Юрьевич