Pathomorphosis of Parkinson's disease on the background of stimulation of the subthalamic nucleus

Bril, E.V.; Tomskiy, A.A.; Gamaleya, A.A.; Poddubskaia, A.A.; Kesarev, D.G.; Omarova, S.M.; Fedorova, N.V.; Levin, O.S.

Авторы: Bril E.V., Tomskiy A.A., Gamaleya A.A., Poddubskaia A.A., Kesarev D.G., Omarova S.M., Fedorova N.V., Levin O.S.
Журнал: Neuroscience and Behavioral Physiology
Том: 55
Номер: 6
Год издания: 2025
Издательство: Kluwer Academic/Plenum Publishers
Местоположение издательства: United States
Первая страница: 1005
Номер статьи: 1010
DOI: 10.1007/s11055-025-01855-3
Аннотация: Objectives. To study the clinical pathomorphosis of Parkinson’s disease (PD) on the background of stimulation of the subthalamic nucleus (DBS STN). Materials and methods. We report here the results of analysis of 15-year follow-up of 401 patients with PD; group 1 (n = 233) consisted of patients who received DBS STN and group 2 (n = 168) consisted of patients who received drug therapy. Analysis of the dynamics of the main motor symptoms of PD was performed using the UPDRS scale and was accompanied by analysis of the survival of patients in both groups. Results. DBS STN significantly alleviated motor symptoms in patients with PD during the off-period: by 57.3% by year 1 and by 23.7% by year 15. Patients did not reach the preoperative state in terms of this indicator. During the on period, the improvement in this group was by 40% and the indicator remained stable for three years, though deterioration was by 200.9% at 15 years due to disease progression. In the second group, progressive deterioration of motor functions was noted by 15 years of observation: by 67.5% in the off period and by 64.5% in the on period (p < 0.05). Univariate analysis of survival showed that patients in group 1 had significantly longer survival than patients in group 2 (p = 0.008). Conclusions. DBS STN alters the clinical pathomorphosis of Parkinson’s disease, leading to less severe parkinsonian symptoms and longer survival.
Добавил в систему: Гамалея Анна Александровна

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Pathomorphosis of Parkinson's disease on the background of stimulation of the subthalamic nucleusстатья

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