|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ПсковГУ |
||
Myosin Class I Genes Follow a Cell Type-Specific Transcription Pattern in Human Haematopoietic Cell Linesстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 апреля 2026 г.
- Авторы: Golysheva Alexandra E., Tvorogova Anna V., Tyukaev Artyom A., Saidova Aleena A., Potashnikova Daria M.
- Журнал: International Journal of Molecular Sciences
- Том: 27
- Номер: 4
- Год издания: 2026
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1777
- Последняя страница: 1777
- DOI: 10.3390/ijms27041777
- Аннотация: Class I myosins form an abundant group of single-headed motor proteins that interact with actin and membrane phospholipids and are employed in a variety of cell processes like cell shape remodeling, motility and invasion, exocytosis, and endocytosis. The large number of class members and their uneven distribution in human cells and tissues complicate their study. Furthermore, this hinders the assessment of their biomarker potential and mechanistic role in oncogenesis and other diseases. Despite the emerging data on their mutations and altered abundance in a number of tumors and other diseases, most studies examine class I myosins individually or in groups of several proteins. Thus, the question of their redundancy and possible functional substitution is ignored. In this work, we simultaneously assess all eight human MYO1 genes on cell lines of different origins by RNA-seq re-analysis. We also report a qPCR system for human myosin I screening and test it on a set of 35 continuous cell lines widely used in biomedicine and fundamental research. These data clarify the restricted expression patterns of MYO1 genes in various human cell types and allow to assess the pattern specific of haematopoietic cell lines.
- Добавил в систему: Поташникова Дарья Марковна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|