Antiviral and Photochemical Properties of Polyaromatic Iodinated Hemicyanines

Krasilnikov, M.S.; Denisov, V.S.; Chumakov, S.P.; Nikitin, T.D.; Orekhov, Y.D.; Lushpa, V.A.; Mazur, R.V.; Gulyak, E.L.; Nikolaenko, Y.I.; Korshun, V.A.; Ustinov, A.V.; Gvozdev, D.A.; Alferova, V.A.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2026 г.

Авторы: Krasilnikov Maxim S., Denisov Vladislav S., Chumakov Stepan P., Nikitin Timofei D., Orekhov Yaroslav D., Lushpa Vladislav A., Mazur Roman V., Gulyak Evgeny L., Nikolaenko Yan I., Korshun Vladimir A., Ustinov Alexey V., Gvozdev Daniil A., Alferova Vera A.
Журнал: ChemistrySelect
Том: 11
Номер: 7
Год издания: 2026
Номер статьи: e06509
DOI: 10.1002/slct.202506509
Аннотация: A series of hemicyanine derivatives was synthesized via condensation of 1,2,3,3-tetramethyl-3H-indolium and its 5-iodo and 4,6-diiodo derivatives with polyaromatic aldehydes. Their spectral properties, singlet oxygen photogeneration, and inhibitory activityagainst vesicular stomatitis virus (VSV) were investigated. The aim of this study was to combine a positive charge for improvedsolubility with either a pyrene or perylene polycycle and heavy iodine atoms to enhance singlet oxygen generation and inducea bathochromic shift in the dye absorption. It was found that the synthesized hemicyanines are unstable both toward variousnucleophiles, particularly the cyanide anion, and toward light. Although the perylene-based derivatives demonstrate antiviralactivity against VSV, the potential application of such compounds lies not in the antiviral domain but rather in the field of chemicalsensors and pH indicators.
Добавил в систему: Гвоздев Даниил Александрович

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Antiviral and Photochemical Properties of Polyaromatic Iodinated Hemicyaninesстатья

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