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Growth Differentiation Factor-9 Stimulates Rat Theca-Interstitial Cell Androgen Biosynthesis1статья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2026 г.
- Авторы: Solovyeva Elena V., Hayashi Masaru, Margi Karen, Barkats Claudine, Klein Cynthia, Amsterdam Abraham, Hsueh Aaron J.W., Tsafriri Alex
- Журнал: Biology of Reproduction
- Том: 63
- Номер: 4
- Год издания: 2000
- Издательство: Society for the Study of Reproduction
- Местоположение издательства: United States
- Первая страница: 1214
- Последняя страница: 1218
- DOI: 10.1095/biolreprod63.4.1214
- Аннотация: Growth differentiation factor-9 (GDF-9) was shown recentlyto be essential for early follicular development, including theappearance of the theca layer. Theca cells provide the androgensubstrate for aromatization and estrogen production by granu-losa cells. Using biologically active recombinant GDF-9 (rGDF-9) and an androgen-producing immortalized theca-interstitialcell (TIC) line or primary TIC, we have examined the action ofthis paracrine hormone on theca cell steroidogenesis. The effectof GDF-9 on TIC progesterone synthesis was marginal and in-consistent in the primary cultures. In immortalized theca cells,GDF-9 attenuated the forskolin-stimulated progesterone accu-mulation. More significantly, this oocyte-derived growth factorenhanced both basal and stimulated androstenedione accumu-lation in the primary and transformed TIC cultures. The effectsof GDF-9 on steroidogenesis by preovulatory follicles were rel-atively modest. Likewise, it did not affect the maturation of fol-licle-enclosed oocytes. The effect of GDF-9, an oocyte product,on TIC androgen production suggests a regulatory role of theoocyte on theca cell function and hence on follicle developmentand differentiation. This direct effect of GDF-9 on thecal ste-roidogenesis is consistent with its recently demonstrated actionson thecal cell recruitment and differentiation.
- Добавил в систему: Соловьева Елена Викторовна