Stepwise release of cargo content by microgel–liposome multicomplex for targeted drug delivery

Zhvanskaya, E.S.; Kozhunova, E.Y.; Efimova, A.A.; Pozdyshev, D.V.; Kazantsev, A.V.; Lukashev, N.V.; Yaroslavov, A.A.

Авторы: Zhvanskaya Elena S., Kozhunova Elena Yu, Efimova Anna A., Pozdyshev Denis V., Kazantsev Alexey V., Lukashev Nikolay V., Yaroslavov Alexander A.
Журнал: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Том: 737
Год издания: 2026
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 139784
DOI: 10.1016/j.colsurfa.2026.139784
Аннотация: This study aims to develop dual-responsive delivery systems based on microgel–liposome complexes, capable of controlled and stepwise cargo release in response to distinct physiological stimuli. Stable multiliposomal complexes were constructed by electrostatic adsorption of small anionic liposomes onto large cationic microgels composed of PNIPAM-co-DADMAC. Two types of liposomes were used: conventional anionic liposomes and pH-sensitive ones incorporating an ampholytic molecular switch. Their release behavior was examined under thermal and pH stimuli. It was shown that the two liposome types responded independently to their respective stimuli: conventional liposomes were disrupted upon microgel collapse above the VPTT (∼32 °C), whereas switch-containing liposomes remained intact under heating but released their cargo upon acidification. The presence of the molecular switch was found to enhance the mechanical stability of the membrane, allowing selective response. Importantly, cytotoxicity assays confirmed that all components—microgels, liposomes, and their complexes—were non-toxic at relevant concentrations. These findings demonstrate that the developed complexes enable two-stage, stimulus-specific release and highlight the potential of microgel–liposome complexes as advanced platforms for smart drug delivery.
Добавил в систему: Хохлов Алексей Ремович

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Stepwise release of cargo content by microgel–liposome multicomplex for targeted drug deliveryстатья

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