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The Potential for Using the Mechanism of Hypoxic Adaptation in Lower Eukaryotesстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2026 г.
- Авторы: Zorov D.B., Zorova L.D., Babenko V.A., Semenovich D.S., Ivanova A.E., Zorov S.D., Pevzner I.B., Plotnikov E.Y., Silachev D.N., Sukhikh G.T.
- Журнал: Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology
- Том: 20
- Номер: 1
- Год издания: 2026
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 9
- Последняя страница: 16
- DOI: 10.1134/S1990747825700527
- Аннотация: This analytical review considers the main elements of mitochondrial restructuring that occurs ineukaryotes forced to live in hypoxic conditions for a long time. In these organisms, mitochondria retain their activity, not only synthetic and signaling, but also bioenergetic, albeit to a lesser extent. The reorganization, primarily accompanied by the reversal of the succinate dehydrogenase reaction and the presence of lowpotential quinone, allows organisms to obtain energy exclusively from complex I in mitochondria. A comprehensive review of all changes caused by constant exposure to hypoxic conditions allows us to develop an antihypoxic strategy that eliminates the influence of undesirable factors associated with hypoxic changes. On the other hand, understanding all elements of hypoxia-induced changes makes it possible to use them in combatingsolid tumor cells that live in the oxygen-deprived microenvironment.
- Добавил в систему: Зоров Дмитрий Бориcович
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