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Study on Kinetics and Biocompatibility Evaluation of Multiple Polymer Layer with Biochemical Material Properties in Drug-Eluting Stentстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 января 2026 г.
- Авторы: Pavlinich Sergey, Liu Xi Wei, Zhao Hong, Li Zhen, Li Li
- Журнал: Advanced materials research
- Том: 644
- Год издания: 2013
- Издательство: Trans Tech Publications
- Местоположение издательства: Stafa-Zurich, Switzerland, Switzerland
- Первая страница: 183
- Последняя страница: 188
- DOI: 10.4028/www.scientific.net/amr.644.183
- Аннотация: This work studied stents eluting paclitaxel (PTX) with a three-layer polymer coating. A concentration of PLGA (poly(lactic-co-glycolic acid)) with a 15% concentration of PEG (polyethylene glycol) in the mixture was used to prepare a multiple drug carrier and was manufactured on the surface of 316L stainless steel stents using an ultrasonic spray coating method. Paclitaxel was investigated in doses of (~255 µg) for the single-layer coated PTX (30 wt.%) and (~275 µg) for the multilayer PTX, coated with PTX accordingly. The surface morphology before and after the exploitation of the multilayer stent was examined using scanning electron microscopy (SEM). The release kinetics of paclitaxel were studied using a comparative release method of single-layer PTX with three-layer polymer PTX. Biocompatibility was also investigated with hemolysis ratio and dynamic clotting time measurements with platelet adhesion.
- Добавил в систему: Павлинич Сергей Николаевич