Pt(IV)-BODIPY Nanoparticles for Photoinduced Tumor Ablation and NIR Light-Activated Chemotherapy

Bykusov, V.; Kuzmichev, I.; Isaeva, Y.A.; Stepanov, M.; Akasov, R.A.; Huang, L.; Gao, S.; Qian, K.; Gorelkin, P.V.; Erofeev, A.S.; Kuanaeva, R.; Nikitin, A.; Nikitina, V.N.; Mamed-Nabizade, V.; Maksimova, Y.; Rodin, I.A.; Vokuev, M.F.; Martynov, A.G.; Bunin, D.; Abakumov, M.A.; Chmelyuk, N.S.; Lazareva, P.; Pokrovsky, V.S.; Khan, I.; Beloglazkina, E.K.; Krasnovskaya, O.O.

Авторы: Bykusov Vladislav, Kuzmichev Ilia, Isaeva Yulia A., Stepanov Maxim, Akasov Roman A., Huang Lin, Gao Si, Qian Kun, Gorelkin Petr V., Erofeev Alexander S., Kuanaeva Regina, Nikitin Aleksey, Nikitina Vita N., Mamed-Nabizade Vugara, Maksimova Yulia, Rodin Igor A., Vokuev Mikhail F., Martynov Alexander G., Bunin Dmitry, Abakumov Maxim A., Chmelyuk Nelly S., Lazareva Polina, Pokrovsky Vadim S., Khan Irina, Beloglazkina Elena K., Krasnovskaya Olga O.
Журнал: ACS Applied Nano Materials
Год издания: 2026
Издательство: American Chemical Society
Местоположение издательства: United States
Номер статьи: acsanm.5c04605
DOI: 10.1021/acsanm.5c04605
Аннотация: hototheranostics, which combine light-induced therapeutic and diagnostic modalities in a single platform, is a novel approach in tumor treatment and diagnostics. The development of dual-action nanomaterials with photothermal activity and the ability to act as photoactivated chemotherapy, capable of the light-induced release of chemotherapeutic agents, is a challenging task. However, different nanosystems reported to date represent either photoactivated chemotherapy (PACT), agents of photothermal therapy (PTT), or the loading of a drug and photoabsorber in a single polymer carrier. Herein, we report a near-infrared-light-activatable theranostic nanoplatform CF3-Pt-NPs with dual antitumor action, PTT/PACT, which is also capable of fluorescent and photothermal imaging of tumor tissues, based on the photoactivated Pt(IV) prodrug CF3-Pt with BODIPY in the axial position. A barrier-free CF3 rotor moiety in the BODIPY core provides excellent photothermal efficacy for the nanoplatform, while both the Pt(IV) prodrug CF3-Pt and nanoparticles CF3-Pt-NPs based on it act as PACT agents by releasing cisplatin under 740 nm light irradiation. Metabolomic profiles of CF3-Pt-NP-treated MCF-7 cells confirmed strong thermal- and cisplatin-induced responses of cells. CF3-Pt-NPs demonstrated the ability to accumulate in vivo in tumors, with the degree of fluorescence in the tumor correlating well with platinum accumulation, thereby confirming the ability of CF3-Pt-NPs to reach the tumor intact. A strong photothermal effect in vivo was confirmed after both intratumoral and intravenous administration of CF3-Pt-NPs with 808 nm laser irradiation. This is the first theranostic nanoplatform with dual PTT/PACT antitumor action, which is also capable of fluorescent and photothermal imaging of tumor tissues.
Добавил в систему: Красновская Ольга Олеговна

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Pt(IV)-BODIPY Nanoparticles for Photoinduced Tumor Ablation and NIR Light-Activated Chemotherapyстатья

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