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In Vitro Drug Release and Hemocompatibility of Biodegradable Plga/Peg Coated Paclitaxel-Eluting Stentsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 января 2026 г.
- Авторы: Pavlinich Sergey, Wei Liu Xi, Li Da Hou, Hong Zhao, Li Zhen, Li Li
- Журнал: Advanced materials research
- Том: 651
- Год издания: 2013
- Издательство: Trans Tech Publications
- Местоположение издательства: Stafa-Zurich, Switzerland, Switzerland
- Первая страница: 49
- Последняя страница: 53
- DOI: 10.4028/www.scientific.net/amr.651.49
- Аннотация: The Paclitaxel-eluting stents (PTX) with biodegradable copolymer coating were studied in investigations. The polymer blend composition of PLGA (polylactic acid-co-glycolic acid) and PEG (polyethylene glycol) has been applied as a drug carrier and fabricated on the surface of 316L stainless steel stents by ultrasonic atomization spraying method. Three doses were explored: low-dose (~80μg per stent, 10 wt%), moderate-dose (~150μg per stent, 20 wt%), and high-dose (~220μg per stent, 30 wt%). The weight ratio of Paclitaxel to PLGA/PEG blends was 10:90, 20:80, and 30:70. Pre- and post-expansion surface morphologies of the Paclitaxel-eluting copolymer coating stents were examined by scanning electron microscopy (SEM). The quantitative analysis of Paclitaxel release in vitro and hemocompatibility by hemolysis ratio and dynamic clotting time measurement were also investigated.
- Добавил в систему: Павлинич Сергей Николаевич