Diffuse infiltrating retinoblastoma: a multicentre,international, data-sharing study

Ankit, S.T.; Finger, P.T.; Gallie, B.; Kivelä, T.T.; Mallipatna, A.; Zhang, C.; Zhao, J.; Wilson, M.W.; Brennan, R.C.; Burges, M.; Berry, J.L.; Jubran, R.; Khetan, V.; Ganesan, S.; Yarovoy, A.; Yarovaya, V.; Kotova, E.; Volodin, D.; Yousef, Y.A.; Nummi, K.; Ushakova, T.L.; Yugay, O.V.; Polyakov, V.G.; Ramirez-Ortiz, M.A.; Esparza-Aguiar, E.; Chantada, G.; Schaiquevich, P.; Fandiño, A.; Yam, J.C.; Lau, W.W.; Lam, C.P.; Sharwood, P.; Moorthy, S.; Long, Q.B.; Essuman, V.A.; Renner, L.A.; Semenova, E.; Catala-Mora, J.; Correa-Llano, G.; Carreras, E.; of AJCC OOTF, o.b.

Авторы: Ankit Singh Tomar, Finger Paul T., Gallie Brenda, Kivelä Tero T., Mallipatna Ashwin, Zhang Chengyue, Zhao Junyang, Wilson Matthew W., Brennan Rachel C., Burges Michala, Berry Jesse L., Jubran Rima, Khetan Vikas, Ganesan Suganeswari, Yarovoy Andrey, Yarovaya Vera, Kotova Elena, Volodin Denis, Yousef Yacoub A., Nummi Kalle, Ushakova Tatiana L., Yugay Olga V., Polyakov Vladimir G., Ramirez-Ortiz Marco A., Esparza-Aguiar Elizabeth, Chantada Guillermo, Schaiquevich Paula, Fandiño Adriana, Yam Jason C., Lau Winnie W., Lam Carol P., Sharwood Phillipa, Moorthy Sonia, Long Quah Boon, Essuman Vera Adobea, Renner Lorna A., Semenova Ekaterina, Catala-Mora Jaume, Correa-Llano Genoveva, Carreras Elisa, of AJCC OOTF on behalf
Журнал: British Journal of Ophthalmology
Том: 109
Номер: 12
Год издания: 2025
Издательство: BMJ Publishing Group
Местоположение издательства: United Kingdom
Первая страница: 1409
Последняя страница: 1416
DOI: 10.1136/bjo-2024-326778
Аннотация: ABSTRACTBackground To determine the unique clinicalcharacteristics and treatment outcomes of diffuseinfiltrating retinoblastoma (DIR).Methods This international, multicentre, registry-basedretrospective case series analysed pooled datafrom January 2001 to December 2013, including132 eyes from 132 patients with DIR.Results Among 2854 eyes with retinoblastoma,132 (4.6%; 95% CI, 3.9 to 5.5) had DIR. Themedian age at diagnosis for DIR patients was24 months (IQR, 15–33), with no bilateralcases of DIR. The American Joint Committee onCancer staging showed 4.5% cT2 and 95.5%cT3 categories, with no cT1 or cT4 cases. Clinicalfeatures associated with DIR included secondaryglaucoma (67%), retinal detachment (38%),diffuse vitreous seeds (37%), anterior segmentinvolvement (24%), vitreous haemorrhage (50%)and hyphema (6%). Primary enucleation was thepredominant treatment (81%), while 19% initiallyreceived systemic chemotherapy, with 6% requiringsubsequent enucleation. The 5-yearKaplan-Meiersurvival rate for cT3 DIR was 82% (95% CI, 78 to86), significantly lower than the 94% (95% CI,93 to 95) for cT3 non-DIRcases (p<0.001). Coxproportional hazards regression returned a higherrisk of metastatic death for DIR cT3 comparedwith non-DIRcT3 (HR, 3.3; 95% CI, 1.8 to 5.9;p<0.001). High-riskpathological features weremore frequent in DIR (41% vs 28%, p=0.004).There was no association between DIR and localtreatment failure.Conclusions Approximately 1 in 20 patients withretinoblastoma had DIR, which often presentedwith glaucoma, anterior segment involvement orintraocular bleeding. DIR was more lethal thannon-DIRcT3, with enucleation revealing high-riskpathology.
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Diffuse infiltrating retinoblastoma: a multicentre,international, data-sharing studyстатья