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Impact of Race on the Outcomes of Retinoblastoma Treated With Primary Enucleation: A Global Study of 1426 Patientsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kaliki Swathi, Vempuluru Vijitha S., Аlia Ahmad, Berry Jesse L., Rosdali Diaz-Coronado, Eiger-Moscovich Maya, Ido Didi Fabian, Grossniklaus Hans, Hubbard G.Baker, Mona Mohammad, Pe'er Jacob, Reddy M.Ashwin, Sagoo Mandeep S., Shields Carol L., Staffieri Sandra E., Tanabe Mika, Ushakova Tatiana, Yacoub A., High-Risk Retinoblastoma Collaborative Study Group
- Журнал: Clinical and Experimental Ophthalmology
- Том: 53
- Год издания: 2025
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Первая страница: 421
- Последняя страница: 434
- DOI: 10.1016/j.ajo.2024.09.023
- Аннотация: ABSTRACTBackground: To evaluate the clinical presentation, pathological features and outcomes of retinoblastoma based on the race oforigin in a global cohort of patients.Methods: Retrospective collaborative study of 1426 patients who underwent primary enucleation for retinoblastoma.Results: Patients were grouped into Caucasians (n = 231, 16%), Asians (n = 841, 59%), Hispanics (n = 226, 16%), Arabs (n = 96,7%) and Others (Africans, African Americans, Indigenous Australians; n = 32, 2%) cohorts. On histopathology, massive choroidalinvasion was higher in Asians (30%) and Hispanics (26%) than Caucasians (15%, p < 0.001). Post-laminaroptic nerveinvasion was higher in Asians (28%), Hispanics (20%) and Others (9%) than Caucasians (11%, p < 0.001). At a mean follow-upof 41 months (median, 35 months; range, < 1–149 months), tumour recurrence and metastasis-relateddeath was higher inHispanics (9% and 12%, respectively), Asians (4% and 13%, respectively) and Others (6% and 6%, respectively). MultivariateCox proportional hazards analysis of outcomes based on race with 8th edition AJCC pT stage and adjuvant therapy as covariatesrevealed 6.8 times greater risk for orbital tumour recurrence in Hispanics compared to Caucasians (p = 0.010) and 3.2times risk hazards for metastasis-relateddeath in Hispanics and Asians compared to Caucasians (p = 0.028 and p = 0.038,respectively).
- Добавил в систему: Ушакова Татьяна Леонидовна