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NEOVASCULAR GLAUCOMA AS A PREDICTOR OF RETINOBLASTOMA HIGH-RISK HISTOPATHOLOGY IN AN INTERNATIONAL MULTICENTER STUDYстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 января 2026 г.
- Авторы: Negretti Guy S., Ushakova Tatiana, Yuri Serov, Vladimir Polyakov, Berry Jesse L., Pike Sarah, Shields Carol L., Hubbard G.Baker, Eiger-Moscovich Maya, Pe'er Jacob, Staffieri Sandra E., Elder James E., McKenzie John D., Ahmad Alia, Hussain Mahvish, Casavilca-Zambrano Sandro, Alarcon-Leon Sandra, Yousef Yacoub A., Mohammad Mona, Tanabe Mika, Arazi Mattan, Fabian Ido Didi, Goldstein Samuel, Kaliki Swathi, Sagoo Mandeep S., Reddy M.Ashwin
- Журнал: Retina
- Номер: 45
- Год издания: 2025
- Издательство: Lippincott Williams & Wilkins Ltd.
- Местоположение издательства: United States
- Первая страница: 565
- Последняя страница: 573
- DOI: 10.1097/IAE.0000000000004340
- Аннотация: Purpose: To assess histopathology and outcomes after primary enucleation of eyes withretinoblastoma presenting with neovascular glaucoma (NVG).Methods: This was an international multicenter case series study across five continents.A retrospective review of patient charts was performed for all patients undergoing primaryenucleation for retinoblastoma (n = 1,420) using a standardized data-collection spreadsheet.Clinical features, pathologic grade, and outcomes were compared between NVGpatients and those with an American Joint Commission on Cancer eighth edition clinicalstage of cT2. High-risk histopathology was defined as American Joint Commission onCancer eighth edition pathologic stage $ pT2b.Results: Neovascular glaucoma was seen in 224/1,420 (16%) patients. The mean age atpresentation of those with NVG was 30 months (median 25, range 0–120 months), and 131(58%) patients had high-risk histopathology. The univariate logistic regression odds ratiofor NVG predicting high-risk histopathology was 1.73 (95% confidence interval: 1.3–2.31)and from multivariate logistic regression was 1.77 (95% confidence interval: 1.23–2.56).Patients with a longer duration of symptoms (P = 0.03), buphthalmos (P = 0.02), andectropion uveae (P , 0.01) were more likely to have high-risk histopathology. Patients withNVG were more likely to develop metastasis than cT2 patients (P = 0.04).Conclusion: There is a significant association between NVG at presentation, high-riskhistopathology, and metastatic risk.
- Добавил в систему: Ушакова Татьяна Леонидовна