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New Benzimidazole 3′-Deoxynucleosides: Synthesis and Antiherpes Virus Propertiesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 января 2026 г.
- Авторы: Arnautova AO, Aleksakhina IA, Zorina EA, Berzina MY, Fateev IV, Eletskaya BZ, Antonov KV, Smirnova OS, Paramonov AS, Kayushin AL, Andronova VL, Galegov GA, Kostromina MA, Zayats EA, Karpenko IL, Kotovskaya SK, Charushin VN, Esipov RS, Miroshnikov AI, Konstantinova ID
- Журнал: Biomolecules
- Том: 15
- Номер: 7
- Год издания: 2025
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 922
- DOI: 10.3390/biom15070922
- Аннотация: A series of new 3'-deoxyribosides of substituted benzimidazoles was obtained by the chemo-enzymatic method using genetically engineered purine nucleoside phosphorylase (PNP). In the case of asymmetrically substituted benzimidazole derivatives, a mixture of N1- and N3-regioisomers was formed (confirmed by NMR). The antiviral activity of the obtained compounds against herpes simplex virus 1 of reference strain L2 and a strain deeply resistant to acyclovir in Vero E6 cell culture was studied. 4,6-Difluoro-1-(β-D-3'-deoxyribofuranosyl)benzimidazole (IC = 250.92 µM, SI = 12.00) and 4,5,6-trifluoro-1-(β-D-3'-deoxyribofuranosyl)benzimidazole (IC = 249.96 µM, SI = 16.00) showed significant selective activity against both viral models in comparison to ribavirin (IC = 511.88 µM, SI 8.00).
- Добавил в систему: Есипов Роман Станиславович