Аннотация:Herein we first attempt to compare catalytic and electrocatalytic properties of the most commonly used peroxidase mimicking nanozymes based on transition metal ions, in-cluding magnetite, cerium oxide, and Prussian Blue. For the nanomaterials under consid-eration, the catalytic rate constant for reducing substrate increases upon decreasing its re-dox potential and reaches the ultimate values for Prussian Blue in the presence of ferro-cyanide (kcat = 3.8 s-1 per single redox-active site). In addition to the highest kcat, Prussian Blue nanoparticles in electrochemical sensors exhibit sensitivity to H2O2 by more than 3 orders of magnitude higher than other nanomaterials. Sensing properties of the electrodes modified with Prussian Blue nanoparticles appear to be dependent on their diameter; par-ticles with diameter of 140 nm provide optimal sensitivity and lifespan of the corre-sponding sensor. The achieved exceptional (electro)catalytic properties of Prussian Blue nanoparticles open the prospects for their application as universal labels for personal an-alyzers with either optical or electrochemical readout.
