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Biocompatible Interpenetrating Network Hydrogels with Dually Cross-Linked Polyolстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 15 октября 2025 г.
- Авторы: Tuleuov Ulygbek B., Kwiatkowski Alexander L., Kazhmuratova Akerke T., Zhaparova Lyazzat Zh, Nassikhatuly Yermauyt, Šlouf Miroslav, Shibaev Andrey V., Petrenko Viktor I., Lanceros-Méndez Senentxu, Tazhbayev Yerkeblan M.
- Журнал: Polymers
- Том: 17
- Год издания: 2025
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 2737
- DOI: 10.3390/polym17202737
- Аннотация: Modern tissue regeneration strategies rely on soft biocompatible materials with adequatemechanical properties to support the growing tissues. Polymer hydrogels have been shownto be available for this purpose, as their mechanical properties can be controllably tuned. Inthis work, we introduce interpenetrating polymer networks (IPN) hydrogels with improvedelasticity due to a dual cross-linking mechanism in one of the networks. The proposedhydrogels contain entangled polymer networks of covalently cross-linked poly(ethyleneglycol) methacrylate/diacrylate (PEGMA/PEGDA) and poly(vinyl alcohol) (PVA) withtwo types of physical cross-links—microcrystallites and tannic acid (TA). Rheologicalmeasurements demonstrate the synergistic enhancement of the elastic modulus of the singlePEGMA/PEGDA network just upon the addition of PVA, since the entanglements betweenthe two components are formed. Moreover, the mechanical properties of IPNs can beindependently tuned by varying the PEGMA/PEGDA ratio and the concentration of PVA.Subsequent freezing–thawing and immersion in the TA solution of IPN hydrogels furtherincrease the elasticity because of the formation of the microcrystallites and OH-bonds withTA in the PVA network, as evidenced by X-ray diffraction and ATR FTIR-spectroscopy,respectively. Structural analysis by cryogenic scanning electron microscopy and lightmicroscopy reveals a microphase-separated morphology of the hydrogels. It promotesextensive contact between PVA macromolecules, but nevertheless enables the formation of a3D network. Such structural arrangement results in the enhanced mechanical performanceof the proposed hydrogels, highlighting their potential use for tissue engineering.
- Добавил в систему: Квятковский Александр Львович