Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgery

Kamshilin, A.A.; Konovalov, A.N.; Grebenev, F.V.; Kozlov, I.O.; Stavtsev, D.D.; Piavchenko, G.A.; Nippolainen, E.; Zaytsev, V.V.; Sokolov, A.Y.; Telyshev, D.V.; Kuznetsov, S.L.; Romashko, R.V.; Meglinski, I.V.

Авторы: Kamshilin Alexei A., Konovalov Anton N., Grebenev Fyodor V., Kozlov Igor O., Stavtsev Dmitry D., Piavchenko Gennadii A., Nippolainen Ervin, Zaytsev Valeriy V., Sokolov Alexey Y., Telyshev Dmitry V., Kuznetsov Sergei L., Romashko Roman V., Meglinski Igor V.
Журнал: FRONTIERS OF OPTOELECTRONICS
Том: 18
Номер: 1
Год издания: 2025
Номер статьи: 20
DOI: 10.1007/s12200-025-00163-5
Аннотация: AbstractIntraoperative assessment of cerebral hemodynamics is crucial for the success of neurosurgical interventions. This studyevaluates the potential of laser speckle contrast imaging (LSCI) and imaging photoplethysmography (IPPG) for contactlessperfusion monitoring during neurosurgery. Despite similarities in their hardware requirements, these techniques rely onfundamentally different principles: light scattering for LSCI and light absorption for IPPG. Comparative experiments wereconducted using animals (rats) when assessing the reaction of cerebral hemodynamics to adenosine triphosphate infusion.The results show different spatial and temporal characteristics of the techniques: LSCI predominantly visualizes bloodflow in large venous vessels, especially in the sagittal and transverse sinuses, showing a pronounced modulation associatedwith the heart that cannot be explained by venous blood flow alone. In contrast, IPPG quantifies the dynamics of perfusionchanges in the parenchyma, showing minimal signal in large venous vessels. We propose that LSCI signal modulation issignificantly influenced by the movement of vessel walls in response to mechanical pressure waves propagating through theparenchyma from nearby arteries. A novel algorithm for LSCI data processing was developed based on this interpretation,producing perfusion indices that align well with IPPG measurements. This study demonstrates that the complementary natureof these techniques (LSCI is sensitive to blood cells displacements, while IPPG detects a change in their density) makes theircombined application particularly valuable for comprehensive assessment of cerebral hemodynamics during neurosurgery
Добавил в систему: Коновалов Антон Николаевич

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Advancing intraoperative cerebral blood flow monitoring: integrating imaging photoplethysmography and laser speckle contrast imaging in neurosurgeryстатья

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