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Plant-Made Antibodies: Properties and Therapeutic Applicationsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 февраля 2018 г.
- Авторы: Komarova T.V., Sheshukova E.V., Dorokhov Y.L.
- Журнал: Current Medicinal Chemistry
- Том: 26
- Номер: 3
- Год издания: 2019
- Издательство: Bentham Science Publishers
- Местоположение издательства: Netherlands
- Первая страница: 381
- Последняя страница: 395
- DOI: 10.2174/0929867325666171212093257
- Аннотация: A cost-effective plant platform for therapeutic monoclonal antibody production is both flexible and scalable. In addition, plant-made antibodies (PMAbs) could be advantageous compared to those produced in animal cells due to the absence of a risk of contamination from nucleic acids or proteins of animal origin. In this review, the various platforms of PMAbs production are described, and the widely used transient expression system based on Agrobacterium-mediated delivery of genetic material into plant cells is discussed in detail. Plants produce less complex and diverse Asn-attached glycans compared to animal cells and contain plant-specific residues. In this review, we examine the features of and approaches to humanizing the Asn297-linked glycan of PMAbs. The prospects for PMAbs in the prevention and treatment of human infectious diseases have been illustrated by promising results with PMAbs against Human immunodeficiency virus, rotavirus infection, Human respiratory syncytial virus, rabies, anthrax and Ebola virus. The pre-clinical and clinical trials of PMAbs against different types of cancer, including lymphoma and breast cancer, are addressed.
- Добавил в систему: Дорохов Юрий Леонидович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Komarova_2019_CMC.pdf | Komarova_2019_CMC.pdf | 1,3 МБ | 9 апреля 2019 [Dorokhov] | |
| 2. | Dr._Komarova-CMC_final_proof.pdf | Dr._Komarova-CMC_final_proof.pdf | 576,6 КБ | 14 марта 2018 [Dorokhov] |