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Diamond nanoneedles for biosensingстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 октября 2025 г.
- Авторы: Quarshie Mariam, Golubewa Lena, Giraulo Caterina, Morello Silvana, Cirillo Claudia, Sarno Maria, Xu Bo, Balasubramanian Priyadharshini, Mindarava Yuliya, Tutkus Marijonas, Obraztsov Alexander, Jelezko Fedor, Kuzhir Polina, Malykhin Sergei
- Журнал: Nanotechnology
- Том: 36
- Год издания: 2025
- Издательство: IOP Publishing
- Местоположение издательства: [Bristol, UK], England
- Номер статьи: 165501
- DOI: 10.1088/1361-6528/adb8f4
- Аннотация: Nanoparticles and nanomaterials are revolutionizing medicine by offering diverse tools fordiagnosis and therapy, including devices, contrast agents, drug delivery systems, adjuvants,therapeutics, and theragnostic agents. Realizing full applied potential requires a deepunderstanding of the interactions of nano dimensional objects with biological cells. In thisstudy, we investigate interaction of single-crystal diamond nanoneedles (SCDNNs) containingsilicon vacancy (SiV-) color centers with biological substances. Four batches of the diamondneedles with sizes ranging between 200 nm and 1300 nm and their water suspensions were usedin these studies. The human lung fibroblast cells were used for the proof-of-conceptdemonstration. Employing micro-photoluminescence (PL) mapping, confocal microscopy, andlactate dehydrogenase (LDH) viability tests, we evaluated the cellular response to the SCDNNs.Intriguingly, our investigation with PL spectroscopy revealed that the cells and SCDNNs cancoexist together with approved efficient registration of SiV- centers presence. Notably, LDHrelease remained minimal in cells exposed to optimally sized SCDNNs, suggesting a smallnumber of lysed cells, and indicating non-cytotoxicity in concentrations of 2–32 μg ml−1. Theevidence obtained highlights the potential of SCDNNs for extra- or/and intracellular drugdelivery when the surface of the needle is modified. In addition, fluorescent defects in theSCDNNs can be used for bioimaging as well as optical and quantum sensing.
- Добавил в систему: Образцов Александр Николаевич