A comparative study of experimental and simulated ultrasound beam propagation through cranial bones

Krokhmal, A.; Simcock, I.C.; Treeby, B.E.; Martin, E.

Авторы: Krokhmal Alisa, Simcock Ian C., Treeby Bradley E., Martin Eleanor
Журнал: Physics in Medicine and Biology
Том: 70
Номер: 2
Год издания: 2025
Издательство: IOP Publishing
Местоположение издательства: [Bristol, UK], England
Первая страница: 025007
Последняя страница: 025007
DOI: 10.1088/1361-6560/ada19d
Аннотация: Objective. Transcranial ultrasound is used in a variety of treatments, including neuromodulation,opening the blood–brain barrier, and high intensity focused ultrasound therapies. To ensure safetyand efficacy of these treatments, numerical simulations of the ultrasound field within the brain areused for treatment planning and evaluation. This study investigates the accuracy of numericalmodelling of the propagation of focused ultrasound through cranial bones. Approach. Hologramsof acoustic fields after propagation through four human skull specimens were measured forfrequencies ranging from 270 kHz to 1 MHz, using both quasi-continuous and pulsed modes. Theopen-source k-Wave toolbox was employed for simulations, using an equivalent-source hologramand a uniform bowl source with parameters that best matched the measured free-field pressuredistribution. Main results. The average absolute error in k-Wave simulations with sound speed anddensity derived from CT scans compared to measurements was 15% for the spatial-peak acousticpressure amplitude, 2.7 mm for the position of the focus, and 35% for the focal volume. Optimiseduniform bowl sources achieved calculation accuracy comparable to that of the hologram sources.Significance. This method is demonstrated as a suitable tool for prediction of focal position, sizeand overall distribution of transcranial ultrasound fields. The accuracy of the shape and position ofthe focal region demonstrate the suitability of the sound speed and density mapping used here.However, large errors in pressure amplitude and transmission loss in some individual cases showthat alternative methods for mapping individual skull attenuation are needed and the possibility ofconsiderable errors in pressure amplitude should be taken into account when planning focusedultrasound studies or interventions in the human brain, and appropriate safety margins should beused.
Добавил в систему: Крохмаль Алиса Александровна

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