Comparative analysis of the effect of hybrid vaterite microparticles with various polysaccharides on neutrophils activity

Grigorieva, D.V.; Mikhalchik, E.V.; Mosievich, D.V.; Mishin, P.I.; Balabushevich, N.G.; Panasenko, O.M.; Sokolov, A.V.; Gorudko, I.V.

Статья опубликована в журнале из списка RSCI Web of Science

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 октября 2025 г.

Авторы: Grigorieva D.V., Mikhalchik E.V., Mosievich D.V., Mishin P.I., Balabushevich N.G., Panasenko O.M., Sokolov A.V., Gorudko I.V.
Журнал: Биомедицинская химия
Том: 71
Номер: 3
Год издания: 2025
Первая страница: 227
Последняя страница: 238
DOI: 10.18097/PBMCR1561
Аннотация: Carriers based on natural biominerals attract much attention in the context of the developmentof new drug delivery systems. In this study, the effects of native (CC) and hybrid vaterite microparticles withthe inclusion of dextran sulfate (CCDS), chondroitin sulfate (CCCS), heparin (CCHE), fucoidan (CCFU), andpectin (CCPE) have been investigated on the viability and functional activity of neutrophils. Among the testedpreparations, only CCFU exhibited a slight cytotoxic effect. Native CC stimulated actin cytoskeleton rearrangementsand cell production of reactive oxygen species (ROS), which decreased in the presence of diphenyleneiodoniumchloride (DPI), an inhibitor of NADPH oxidase assembly. The CC-induced NADPH oxidase activation was reducedin the presence of inhibitors of non-receptor tyrosine kinases of the Src family, phosphatidylinositol 3-kinase (PI3K),and phospholipase C (PLC). Similar to native CC, hybrid vaterite microparticles also initiated ROS productionby neutrophils. After addition of CC and hybrid vaterite microparticles (except CCDS), an increase in the numberof neutrophils characterized by higher values of the side scattering value was detected thus indicatinga change in the morphological characteristics of the cells. Given the ability of hybrid vaterite microparticleswith polysaccharides to activate neutrophil NADPH oxidase, they could be promising systems for the deliveryof antibacterial and antiviral drugs.
Добавил в систему: Балабушевич Надежда Георгиевна

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Comparative analysis of the effect of hybrid vaterite microparticles with various polysaccharides on neutrophils activityстатья

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