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Cell response kinetics: the phenomenon of supercooperativity in aggregation of human plateletsстатья
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 декабря 2014 г.
- Авторы: Vrzheshch P.V., Tatarintsev A.V., Ershov D.E., Varfolomeev S.D.
- Журнал: Thrombosis Research
- Том: 66
- Номер: 5
- Год издания: 1992
- Издательство: Pergamon Press
- Местоположение издательства: United States
- Первая страница: 537
- Последняя страница: 547
- DOI: 10.1016/0049-3848(92)90308-W
- Аннотация: Concentration - response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 < hPMA < hA23187 < hMERTHIOLATE = hARACHIDONATE. The results were interpreted in terms of a model assuming varying degrees of cooperativity for each step of signal transduction involved in platelet aggregation. Super-high values of h (>30) obtained with arachidonate and merthiolate, as well as in the case of inhibition of an arachidonate-induced response by indomethacin and PTA 2, suggested that at least one region of signal transduction pathway leading to aggregation exhibited supercooperative properties.
- Добавил в систему: Вржещ Петр Владимирович