Terahertz nanoantenna sensor for detection of biomarker L-2-Hydroxyglutarate, design optimization and testing

Авторы: Cherkasova Olga P., Kuznetsov Sergei A., Rybak Alina A., Konnikova Maria R., Utkin Dmitry E., Nikolaev Nazar A.
Журнал: Optical and Quantum Electronics
Том: 57
Номер: 6
Год издания: 2025
Издательство: Springer Nature
Местоположение издательства: Switzerland
Номер статьи: 340
DOI: 10.1007/s11082-025-08260-7
Аннотация: L-2-Hydroxyglutarate (L-2HG) plays a significant role in many physiological processes and is considered as a biomarker for various types of oncology. So, its rapid and quantitative measurement in tissues and body fluids is of great clinical importance. The goal of this work is to develop highly efficient photonic sensor for L-2HG using the effect of nanoantenna-assisted plasmonic enhancement of terahertz absorption. We present the numerical results of the design optimization for L-2HG sensor based on Si/SiO2-wafer-backed arrays of golden nanoantennas (NA) of linear geometry for the resonant frequency of 1.337 THz. NA sensor was fabricated by nanolithography, characterized by scanning electron microscope and tested with terahertz time-domain spectroscopy (THz-TDS). Experimental validation of the NA sensor showed its specific sensitivity to L-2HG. A number of methods have been proposed to improve the accuracy of the NA sensor characterized using THz-TDS technique by an order of magnitude.
Добавил в систему: Конникова Мария Руслановна

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