Аннотация:Heterotopic pancreatic tissue located in the wall of the duodenum is an uncommon clinical condition that can resemblean intraductal tumor. Typically, it is identified incidentally during clinical evaluations. Most patients remain asymptomatic,and any clinical symptoms that do occur are nonspecific, varying based on the characteristics of the lesionand any associated complications. Despite the considerable advancements in various endoscopic and interventionaldiagnostic techniques, this anatomical and clinical scenario continues to pose a complex and contentious challenge.Endoscopic papillectomy has emerged as a minimally invasive and effective treatment option for this condition. In thisarticle, we share our experience with endoscopic papillectomy as both a therapeutic and diagnostic method for heterotopicpancreatic tissue in the duodenal wall that mimics an intraampullary tumor. Additionally, we provide a comprehensivereview of the current literature on this subject, outline the clinical presentation, diagnosis, and management of thiscondition, and propose a procedural algorithm for endoscopic papillectomy.