|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ПсковГУ |
||
Determination of 3-(4-Hydroxyphenyl)lactic Acid by an Amperometric Sensor with Molecularly Imprinted Polymersстатья
- Авторы: Korovkina A.O., Yen Vu Hoang, Beloborodova N.V., Vybornyi A.Yu, Zyablov A.N.
- Журнал: Journal of Analytical Chemistry
- Том: 79
- Номер: 11
- Год издания: 2024
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1635
- Последняя страница: 1639
- DOI: 10.1134/s1061934824701065
- Аннотация: Sepsis is a life-threatening organ dysfunction caused by a disorder in the regulation of a body's response to infection. If sepsis is not recognized at an early stage and treatment is not started, it can lead to septic shock, multiple organ failure, and death. Sepsis diagnostics, traditionally based on the clinical picture and the detection of etiologically significant microorganisms in the blood and foci, has been improved in recent years through the search for and the implementation of various biomarkers. One of promising sepsis biomarkers is 3-(4-hydroxyphenyl)lactic acid (4-HPLA). In this work, an amperometric sensor modified with a molecularly imprinted polymer (MIP) of hydroxyphenyllactic acid is developed, and a fundamental possibility of determining 4-HPLA in model aqueous solutions using this sensor is demonstrated. Molecularly imprinted polymers are widely used in substance separation processes and in the fabrication of selective sensors..
- Добавил в систему: Белобородова Наталья Владимировна