Smart Bio-Nanocoatings with Simple Post-Synthesis Reversible Adjustmentстатья
Статья опубликована в высокорейтинговом журнале
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Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 октября 2025 г.
Аннотация:Nanopatterning of signal-transmitting proteins is essential for cell physiologyand drug delivery but faces challenges such as high cost, limited pattern variability, andnon-biofriendly materials. Arthropods, particularly beetles (Coleoptera), offer a naturalmodel for biomimetic nanopatterning due to their diverse corneal nanostructures. Usingatomic force microscopy (AFM), we analyzed Coleoptera corneal nanocoatings and identifieddimpled nanostructures that can transform into maze-like/nipple-like protrusions.Further analysis suggested that these modifications result from a temporary, self-assembledprocess influenced by surface adhesion. We identified cuticular protein 7 (CP7) as a keycomponent of dimpled nanocoatings. Biophysical analysis revealed CP7’s unique selfassemblyproperties, allowing us to replicate its nanopatterning ability in vitro. Our findingsdemonstrate CP7’s potential for bioinspired nanocoatings and provide insights intothe evolutionary mechanisms of nanostructure formation. This research paves the way forcost-effective, biomimetic nanopatterning strategies with applications in nanotechnologyand biomedicine.