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SLC6A3 (DAT1) as a Novel Candidate Biomarker Gene for Suicidal Behaviorстатья
- Авторы: Rafikova Ekaterina, Shadrina Maria, Slominsky Peter, Guekht Alla, Ryskov Alexey, Shibalev Dmitry, Vasilyev Vasiliy
- Журнал: Genes
- Том: 12
- Номер: 6
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 861
- Последняя страница: 861
- DOI: 10.3390/genes12060861
- Аннотация: It has been previously shown that the serotonin and dopamine neurotransmitter systemsmight influence the predisposition to suicidal behavior. This study aims to estimate the contributionof 11 polymorphisms in the genes SLC6A4 (5HTT), HTR1A, HTR2A, HTR1B, SLC6A3 (DAT1), DRD4,DRD2, COMT, and BDNF to suicidal behavior and severity of symptoms of depression and anxietyin the Russian population. The study was performed on 100 patients with repeated suicide attemptsand 154 controls. We first found an association between SLC6A3 (DAT1) 40 bp VNTR locus andsuicidal behavior. This association was significant; when using the codominant (p = 0.006), dominant(p = 0.001), overdominant (p = 0.004), and log-additive (p = 0.004) models, LL genotype played aprotective role (OR = 0.48, 0.29–0.82, p = 0.005). Difference in the distribution of COMT rs4680genotypes was significant in the codominant (p = 0.04), dominant (p = 0.013), and log-additive(p = 0.02) models, and AA genotype might protect against suicide (OR = 0.49, 0.26–0.91, p = 0.025).SLC6A4 5-HTTLPR + rs25531 locus was significant in the recessive model (p = 0.024), and alsoaffected the severity of symptoms of depression (p = 0.044) and personal anxiety (p = 0.029). Ourresults suggest that allelic variants of SLC6A3, COMT, and SLC6A4 genes might be considered as riskfactors for suicidal attempts.
- Добавил в систему: Васильева Александра Александровна