Аннотация:Somatic multiple drug resistance (MDR) is a poorly understood
phenomenon which was primarily manifested in the
treatment of cancer. It is characterized by a reduced susceptibility
of tumor cells to antitumor drugs due to a release the
drugs out of the cells. So called drug resistance proteins are
responsible for this phenomenon that act like pumps. Prolonged
use of drugs leads to enhanced expression of the genes
encoding these proteins and their increased activity. Such cellular
resistance makes sense in survival of somatic cells when
exposed to different harmful substances. Here we have shown
that tuberculosis infection itself causes increased expression
of mdr1a and mdr1b MDR proteins that along with the possible
development of cellular resistance to anti-TB drugs complicates
the treatment of tuberculosis.
