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Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1статья Исследовательская статья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 декабря 2024 г.
- Авторы: Fetisova EK, Vorobjeva NV, Muntyan MS
- Журнал: Advances in Gerontology
- Том: 14
- Номер: 2
- Год издания: 2024
- Первая страница: 35
- Последняя страница: 48
- DOI: 10.1134/S2079057024600630
- Аннотация: The research from Advances in Gerontology on "Multiple Sclerosis. Some Features of Pathology and Prospects for Therapy. Part 1" is free to read due to Springer Nature initiative. The link to learn it is https://rdcu.be/d1BaK ---------------------------------------------------- ------------ The study is dedicated to the glowing memory of the outstanding biochemist, our adviser, Academician Vladimir Petrovich Skulachev ----------------------------------------------------- Multiple sclerosis (MS) is among the most common diseases of the central nervous system. The disease leads to pathological demyelination of axons in the white matter of the brain, followed by demyelination of gray matter, and is accompanied by progressive neurodegeneration in patients. The etiology of the disease is not fully understood. However, a number of external and internal factors that increase the likelihood of MS among the active capable part of the population have been established. The characteristics of age patients exacerbating the course of MS have been identified. The review discusses the mechanism of inflammation activation at MS involving NLRP3 inflammasome and neutrophils identified in recent years, the effect of inflammation on damage to the blood-brain barrier and MS progression, as well as reactive oxygen species-mediated participation of mitochondria in MS pathology development.
- Добавил в систему: Воробьева Нина Викторовна
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