Voltage-Dependent Calcium Channels in Mammalian Motor Synapses: Triggers and Modulators  of Neuromuscular Transmission

Gaydukov, A.E.; Balezina, O.P.

Авторы: Gaydukov A.E., Balezina O.P.
Журнал: Journal of Evolutionary Biochemistry and Physiology
Том: 60
Номер: 5
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 1975
Последняя страница: 2004
DOI: 10.1134/s0022093024050259
Аннотация: The initiation of the fast synchronous quantal release of neurotransmitters in central and peripheral synapses is ensured by a local increase in the concentration of Ca2+ ions in the nerve terminals near the Ca2+ sensors of synaptic vesicles in response to depolarization of the presynaptic membrane by an action potential (AP) propagating along the axon. Ca2+ entry into the nerve terminal through presynaptic voltage-dependent Ca2+ channels CaV2.1 or CaV2.2 (P/Q- or N-type) is the main route to form a dynamic Ca2+ signal that triggers the process of exocytosis of synaptic vesicles in virtually all types of chemical synapses and is able to induce the development of certain Ca2+-dependent forms of synaptic plasticity. However, in recent years it has become obvious that the set of sources and the spectrum of presynaptic Ca2+ signals are very diverse. Identification of the ensemble of regulatory Ca2+ entries co-operating with their targets, as well as characterization of their contribution to the mechanisms controlling quantal neurotransmitter release, is a topical area of modern synaptic physiology. Among the Ca2+ entries additional to those involved in triggering vesicular endocytosis, L-type Ca2+ channels are of particular interest. Their function and activation conditions in neuromuscular junctions (NMJs) are poorly studied, providing no unambiguous idea of the role of this Ca2+ entry in the regulation of acetylcholine (ACh) release in vertebrate motor synapses. This review systematizes the currently available data on the diverse functional role of voltage-gated Ca2+ channels in mammalian NMJs and presynaptic signaling pathways that control these Ca2+-inputs and their implication in the processes of fine-tuning ACh quantal release.
Добавил в систему: Гайдуков Александр Евгеньевич

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Voltage-Dependent Calcium Channels in Mammalian Motor Synapses: Triggers and Modulators of Neuromuscular Transmissionстатья Исследовательская статья

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