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Influence of natural polysaccharides on the morphology and properties of hybrid vaterite microcrystalsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 10 июля 2024 г.
- Авторы: Balabushevich Nadezhda G., Maltseva Liliya N., Filatova Lyubov Y., Mosievich Daniil V., Mishin Pavel I., Bogomiakova Margarita E., Lebedeva Olga S., Murina Marina A., Klinov Dmitry V., Obraztsova Ekaterina A., Kharaeva Zaira F., Firova Roxalana K., Grigorieva Daria V., Gorudko Irina V., Panasenko Oleg M., Mikhalchik Elena V.
- Журнал: Heliyon
- Том: 10
- Номер: 13
- Год издания: 2024
- Издательство: Elsevier Science Publishing Company, Inc.
- Местоположение издательства: Нидерланды
- Первая страница: 1
- Последняя страница: 16
- Номер статьи: e. 33801
- DOI: 10.1016/j.heliyon.2024.e33801
- Аннотация: Co-precipitation of biopolymers into calcium carbonate crystals changes theirphysicochemical and biological properties. This work studies hybrid microcrystals of vateriteobtained in the presence of natural polysaccharides, as carriers for the delivery of proteins andenzymes. Hybrid microcrystals with dextran sulfate, chondroitin sulfate, heparin, fucoidan, andpectin were obtained and compared. The impact of polysaccharides on the morphology (particlediameter, surface area, nanocrystallite and pore size), polysaccharide content and surface chargeof hybrid microcrystals was studied. Only microcrystals with fucoidan and heparin exhibitedantioxidant activity against •ОН radical. The surface charge and pore size of the hybridmicrocrystals affected the sorption of albumin, catalase, chymotrypsin, mucin. A decrease in thecatalytic constant and Michaelis constant was observed for catalase sorbed on the hybrid crystals.The biocompatibility of microcrystals depended on the nature of the included polysaccharide:crystals with sulfated polysaccharides increased blood plasma coagulation but not plateletaggregation, and crystals with dextran sulfate had the greatest cytotoxicity against HT-29 cells butnot erythrocytes. Hybrid microcrystals with all polysaccharides except chondroitin sulfate reducederythrocyte lysis in vitro compared with vaterite crystals. The obtained results enable to createnovel carriers based on hybrid vaterite crystals with polysaccharides, beneficial for the delivery ofprotein drugs
- Добавил в систему: Балабушевич Надежда Георгиевна
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