Recent Advances in the Synthesis of Peptidomimetics via Ugi Reactions

Liu, C.; Voskressensky, L.G.; Van der Eycken, E.V.

Авторы: Liu Chao, Voskressensky Leonid G., Van der Eycken Erik V.
Журнал: Chemistry - A European Journal
Том: 30
Номер: 14
Год издания: 2024
Издательство: John Wiley & Sons Ltd.
Местоположение издательства: United Kingdom
Номер статьи: e202303597
DOI: 10.1002/chem.202303597
Аннотация: Peptidomimetics have been extensively explored in many area due to their ability to improve pharmacological qualities and interesting biological activities. Cycles could be incorporated in peptides to reduce their flexibility, often enhancing the affinity for a certain receptor. Many efforts have been made to synthesize various peptidomimetics. Among them, the Ugi reaction is a popular way for the synthesis of peptidomimetics because it provides peptide\u2010like products. The Ugi reaction consists of the condensation of an aldehyde or ketone, a carboxylic acid, an amine, and an isocyanide usually giving a linear peptidomimetic. In order to obtain other linear, cyclic or polycyclic peptidomimetics, the acyclic products have to undergo additional transformations or cyclizations. This review covers the years from 2018\u20132023, regarding the synthesis of linear, cyclic and polycyclic peptidomimetics, employing Ugi reactions eventually followed by post- transformations. Organo-catalyzed reactions, base-promoted reactions, and metal-free reactions toward peptidomimetics are highlighted
Добавил в систему: Малошицкая Ольга Александровна

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Recent Advances in the Synthesis of Peptidomimetics via Ugi Reactionsстатья