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Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injuryстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 мая 2024 г.
- Авторы: Kutumova Elena O., Akberdin Ilya R., Egorova Vera S., Kolesova Ekaterina P., Parodi Alessandro, Pokrovsky Vadim S., Zamyatnin Jr Andrey A., Kolpakov Fedor A.
- Журнал: Heliyon
- Том: 10
- Номер: 10
- Год издания: 2024
- Издательство: Elsevier Science Publishing Company, Inc.
- Местоположение издательства: Нидерланды
- Номер статьи: e30962
- DOI: 10.1016/j.heliyon.2024.e30962
- Аннотация: The application of nanomedicine in the treatment of acute lung injury (ALI) has great potential for the development of new therapeutic strategies. To gain insight into the kinetics of nanocarrier distribution upon time-dependent changes in tissue permeability after ALI induction in mice, we developed a physiologically based pharmacokinetic model for albumin nanoparticles (ANP). The model was calibrated using data from mice treated with intraperitoneal LPS (6 mg/kg), followed by intravenous ANP (0.5 mg/mouse or about 20.8 mg/kg) at 0.5, 6, and 24 h. The simulation results reproduced the experimental observations and indicated that the accumulation of ANP in the lungs increased, reaching a peak 6 h after LPS injury, whereas it decreased in the liver, kidney, and spleen. The model predicted that LPS caused an immediate (within the first 30 min) dramatic increase in lung and kidney tissue permeability, whereas splenic tissue permeability gradually increased over 24 h after LPS injection. This information can be used to design new therapies targeting specific organs affected by bacterial infections and potentially by other inflammatory insults.
- Добавил в систему: Замятнин Андрей Александрович