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Antimicrobial Metabolites from Pig Nasal Microbiotaстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.
- Авторы: Baranova A.A., Zakalyukina Y.V., Tyurin A.P., Korshun V.A., Belozerova O.A., Biryukov M.V., Moiseenko A.V., Terekhov S.S., Alferova V.A.
- Журнал: Russian Journal of Bioorganic Chemistry
- Том: 50
- Номер: 2
- Год издания: 2024
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 354
- Последняя страница: 374
- DOI: 10.1134/s1068162024020237
- Аннотация: Objective: Isolation of bacteria and fungi from porcine nasal microbiome and evaluation of antibioticproducing potential among them. Methods: Conventional isolation using Sabouraud and Mueller-Hinton nutrient media was carried out for collected samples. The isolated strains were subjected to antibiotic susceptibility testing and antimicrobial activity screening. Results and Discussion: Taxonomy positions of the 20 isolated strains (18 bacteria, 1 yeast, 1 fungus) were determined by phylogenetic analysis, morphological study and a substrate utilization assay. Pseudomonas aeruginosa SM-11 was found to produce 4 known antibacterial molecules (pyocyanine, pyochelin, pyoluteorin, monorhamnolipid). Production of pyocyanine was induced by cocultivation with test microorganisms. Conclusions: The mammal microbiota might serve as a valuable source of antimicrobialproducing strains, including those of rare taxa. Cocultivation techniques are a promising approach to exploring antimicrobials from silent biosynthetic gene clusters.
- Добавил в систему: Баранова Анна Александровна