Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potential

Kozlov, V.A.; Aleksanyan, D.V.; Churusova, S.G.; Spiridonov, A.A.; Rybalkina, E.Y.; Gutsul, E.I.; Aksenova, S.A.; Korlyukov, A.A.; Peregudov, A.S.; Klemenkova, Z.S.

Авторы: Kozlov Vladimir A., Aleksanyan Diana V., Churusova Svetlana G., Spiridonov Aleksandr A., Rybalkina Ekaterina Yu, Gutsul Evgenii I., Aksenova Svetlana A., Korlyukov Alexander A., Peregudov Alexander S., Klemenkova Zinaida S.
Журнал: International Journal of Molecular Sciences
Том: 24
Номер: 24
Год издания: 2023
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Номер статьи: 17331
DOI: 10.3390/ijms242417331
Аннотация: Driven by the growing threat of cancer, many research efforts are directed at developingnew chemotherapeutic agents, where the central role is played by transition metal complexes. Theproper ligand design serves as a key factor to unlock the anticancer potential of a particular metalcenter. Following a recent trend, we have prepared unsymmetrical pincer ligands that combinebenzothiazole and thiocarbamate donor groups. These compounds are shown to readily undergodirect cyclopalladation, affording the target S,C,N-type Pd(II) pincer complexes both in solutionand in the absence of a solvent. The solid-phase strategy provided the complexes in an efficientand ecologically friendly manner. The resulting palladacycles are fully characterized using nuclearmagnetic resonance (NMR) and infrared (IR) spectroscopy and, in one case, by single-crystal X-raydiffraction (XRD). The solvent-free reactions are additionally analyzed by powder XRD. The pincercomplexes exhibit remarkable cytotoxicity against several solid and blood cancer cell lines, includinghuman colorectal carcinoma (HCT116), breast cancer (MCF7), prostate adenocarcinoma (PC3), chronicmyelogenous leukemia (K562), multiple plasmacytoma (AMO1), and acute lymphoblastic leukemia(H9), with the dimethylamino-substituted derivative being particularly effective. The latter alsoinduced an appreciable level of apoptosis in both parental and doxorubicin-resistant cells K562 andK562/iS9, vindicating the high anticancer potential of this type of palladacycles.
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Unsymmetrical Pd(II) Pincer Complexes with Benzothiazole and Thiocarbamate Flanking Units: Expedient Solvent-Free Synthesis and Anticancer Potentialстатья

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