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Effect of the Synthetic Peptide LKEKK on Psoriasisстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Navolotskaya E.V., Sadovnikov V.B., Zinchenko D.V., Murashev A.N.
- Журнал: Russian Journal of Bioorganic Chemistry
- Том: 49
- Номер: 6
- Год издания: 2023
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1346
- Последняя страница: 1352
- DOI: 10.1134/s1068162023060158
- Аннотация: It has been established that the synthetic peptide LKEKK affects the ability of IL-12 to control the secretory activity of keratinocytes isolated from psoriatic human skin: in the concentration range of 100–1000 nM, it enhanced in a dose-dependent manner IL-12-induced production of IL-10 and IFN-γ and inhibition of IL-17 secretion in vitro. The peptide with the inverted KKEKL sequence was inactive, indicating a high specificity of the action of the LKEKK peptide. The in vivo study of the activity of the LKEKK peptide in a mouse model of imiquimod-induced psoriasis showed that the daily application of 150–500 μg of the peptide together with Aldara cream containing 5% imiquimod on the ear for 6 days significantly suppressed the development of the inflammatory process. Thus, the LKEKK peptide is suitable as a basis for the development of drugs for treatment of psoriasis and other inflammatory skin diseases.
- Добавил в систему: Зинченко Дмитрий Валерьевич