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Methods for Analysis of Interactome of Microproteins Encoded by Short Open Reading Framesстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Sedlov I.A., Fesenko I.A.
- Журнал: Russian Journal of Bioorganic Chemistry
- Том: 49
- Год издания: 2023
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 717
- Последняя страница: 730
- DOI: 10.1134/S1068162023040179
- Аннотация: Recent studies demonstrated that short open reading frames (sORFs, <100 codons) can encode the peptides or microproteins that perform important functions in prokaryotic and eukaryotic cells. It was established that the products of sORF translation are involved in the regulation of many processes; for example, they modulate the activity of the mitochondrial respiratory chain or the activity of muscle cells in mammals. However, the identification and subsequent functional analysis of the peptides or microproteins encoded by sORF is a nontrivial task that requires the use of special approaches. The discovery of partner proteins for the studied peptide is one of the critical stages in functional analysis. This review considers the peculiarities of the analysis of the interactome of sORF-encoded microproteins and describes the approaches currently used for such studies.
- Добавил в систему: Седлов Илья Андреевич