Аннотация:150 patients with mild and moderate hypertension were treated with Inderal (Obsidan) and 68 with Visken. The best results were obtained in patients with a hyperkinetic type of circulation. Haemodynamic studies showed a decrease in heart rate and cardiac output beginning on the 5th day of therapy (determined by means of impedance rheography of the thorax). The maximum decrease (26 %) was found after 2 - 4 weeks of therapy. The concomitant increase in peripheral vascular resistance was less pronounced (11 %). The hypotensive effect developed within 2 - 3 weeks after starting Visken therapy. Inderal has a more rapid onset of action.During treatment with beta-receptor blocking agents we observed a significant improvement in cerebral circulation and favourable haemodynamic response to physiological stresses such as Valsava's man Oeuvre and sudden upward tilting of the head. After 3 - 4 weeks' therapy with Inderal there was practically no decrease in stroke volume. These data suggest an increase in venous tone and venous blood return due to concurrent stimulation of alpha-receptor activity.Inderal caused varying effects on plasma renin activity. A reduction in this activity was observed in patients with initially high plasma renin, and this coincided with an increase in total blood volume. In cases where blood volume was reduced, renin activity increased.During continued therapy in 117 patients, normotensive levels were maintained only in patients regularly receiving adequate doses of Inderal or Visken. Combining with diuretics or hydralazine enhances the effects of beta-receptor blocking agents.Our trial with Brinerdin shows that this is a valuable and rational combination of hypotensive agents. It proved possible to achieve a satisfactory effect in patients with moderate to severe hypertension. No significant changes in the electrolyte balance were observed when small doses of Brinerdin were used.
