Total recall: the role of PIDDosome components in neurodegeneration

Авторы: Volik Pavel I., Kopeina Gelina S., Zhivotovsky Boris, Zamaraev Alexey V.
Журнал: Trends in Molecular Medicine
Том: 29
Номер: 12
Год издания: 2023
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 996
Последняя страница: 1012
DOI: 10.1016/j.molmed.2023.08.008
Аннотация: Caspase-2 activity modulates AMP receptor trafficking and dendritic spine dynamics.A soluble tau fragment generated by caspase-2 is elevated in Alzheimer’s disease, Huntington's disease, and Lewy body disease and promotes cognitive defects.The genetic ablation of caspase-2 leads to symptomatic benefits in transgenic mice overexpressing mutant huntingtin or the amyloid-β precursor protein.Biallelic mutations in genes encoding p53-induced protein with a death domain 1, receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain cause intellectual, behavioral, and psychological abnormalities of varying severity, predominantly accompanied by pachygyria.Selective PIDDosome component inhibitors protect against neurotoxicity in in vitro models, which makes them promising therapeutic agents for the treatment of neurodegenerative diseases.
Добавил в систему: Копеина Гелина Сергеевна

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