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IDENTIFICATION, SEQUENCE-ANALYSIS, AND CHARACTERIZATION OF CDNA CLONES ENCODING 2 GRANZYME-LIKE SERINE PROTEINASES FROM RAT DUODENUMстатья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: AMERIK AY, YAROVOI SV, GRIGORENKO VG, ANTONOV VK
- Журнал: FEBS Letters
- Том: 324
- Номер: 2
- Год издания: 1993
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 226
- Последняя страница: 230
- DOI: 10.1016/0014-5793(93)81398-J
- Аннотация: Clones of cDNA encoding two serine proteinases were isolated from a cDNA library prepared from rat duodenum mRNA. The deduced amino acid sequences consisted of 248 residues and possessed a high level of homology to one another and to the sequences of granzymes, cathepsin G, and mast cell proteases I and II. Analysis of the enzymes' primary structures allowed the identification of the catalytic amino acid triad and the prediction of the substrate specificity. Northern blotting experiments showed that while one of these proteinases is expressed only in duodenum, the other enzyme is present in duodenum, lung, and spleen. It is supposed that these proteinases may play an important role in the function of an organism's defence systems.
- Добавил в систему: Григоренко Виталий Георгиевич