|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ПсковГУ |
||
Repeated positive fighting experience in male inbred miceстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 ноября 2021 г.
- Авторы: Kudryavtseva N.N., Smagin D.A., Kovalenko I.L., Vishnivetskaya G.B.
- Журнал: Nature Protocols
- Том: 9
- Номер: 11
- Год издания: 2014
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- Первая страница: 2705
- Последняя страница: 2717
- DOI: 10.1038/nprot.2014.156
- Аннотация: Repeated aggression is a frequent symptom of many psychiatric and neurological disorders, including obsessive-compulsive and attention deficit hyperactivity disorders, bipolar and post-traumatic stress disorders, epilepsy, autism, schizophrenia and drug abuse. However, repeated aggression is insufficiently studied because there is a lack of adequate models in animals. The sensory contact model (SCM), widely used to study the effects of chronic social defeat stress, can also be used to investigate the effects of repeated aggression. Mice with repeated positive fighting experience in daily agonistic interactions in this model develop pronounced aggressiveness, anxiety and impulsivity, disturbances in motivated and cognitive behaviors, and impairments of sociability; they also demonstrate hyperactivity, attention-deficit behavior, motor dysfunctions and repetitive stereotyped behaviors, such as jerks, rotations and head twitches. In this protocol, we describe how to apply the SCM to study repeated aggression in mice. Severe neuropathology develops in male mice after 20-21 d of agonistic interactions.
- Добавил в систему: Галямина Анна Георгиевна