Аннотация:Objective: To evaluate the relationship between the measurement of blood flow in a tumor based on perfusion imaging using spin labeling of arteries (ASL-PI) and histopathological findings in gliomas of various grades of malignancy.Methods: This study included 20 patients (10 high grade gliomas and 10 low grade gliomas). All patients received a multiphase multislice ASL MRI pulse sequence. As an index of tumor perfusion, the relative signal intensity (SI) of each tumor (% signal intensity) was defined as a percentage of maximum tumor SI per mean SI in normal gray matter of the brain on ASL-PI. Relative vascular attenuation was defined as the total area of microvessels over the entire tissue area in histopathological specimens. The indicators of MIB1 gliomas were also calculated. Differences in percentage signal intensity were compared between different histopathological types and between high and low grade gliomas. The correlation between ASL perfusion and the degree of glioma anaplasia was assessed using Spearman's correlation analysis.Results: There was a statistically significant difference between low and high grade tumors. Correlation analysis revealed significant positive correlations between tumor grade and ASL-PI perfusion (p <0.002).Conclusion. ASL-PI is an effective imaging technique for non-invasive assessment of tumor perfusion and can predict histopathological vascular density of glial brain tumors and may be useful in distinguishing between high and low grade gliomas.
