Yeast Translational Activator Mss51p and Human ZMYND17 – Two Proteins with a Common Origin, but Different Functions

Baleva, M.V.; Piunova, U.E.; Chicherin, I.V.; Krasavina, D.G.; Levitskii, S.A.; Kamenski, P.A.

Авторы: Baleva Maria V., Piunova Uliyana E., Chicherin Ivan V., Krasavina Darya G., Levitskii Sergey A., Kamenski Piotr A.
Журнал: Biochemistry (Moscow)
Том: 86
Номер: 9
Год издания: 2021
Издательство: Pleiades Publishing, Ltd
Местоположение издательства: Road Town, United Kingdom
Первая страница: 1151
Последняя страница: 1161
DOI: 10.1134/s0006297921090108
Аннотация: Despite its similarity to protein biosynthesis in bacteria, translation in the mitochondria of modern eukaryotes has several unique features, such as the necessity for coordination of translation of mitochondrial mRNAs encoding proteins of the electron transport chain complexes with translation of other protein components of these complexes in the cytosol. In the mitochondria of baker’s yeast Saccharomyces cerevisiae, this coordination is carried out by a system of translational activators that predominantly interact with the 5′-untranslated regions of mitochondrial mRNAs. No such system has been found in human mitochondria, except a single identified translational activator, TACO1. Here, we studied the role of the ZMYND17 gene, an ortholog of the yeast gene for the translational activator Mss51p, on the mitochondrial translation in human cells. Deletion of the ZMYND17 gene did not affect translation in the mitochondria, but led to the decrease in the cytochrome c oxidase activity and increase in the amount of free F1 subunit of ATP synthase. We also investigated the evolutionary history of Mss51p and ZMYND17 and suggested a possible mechanism for the divergence of functions of these orthologous proteins.
Добавил в систему: Каменский Петр Андреевич

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ПсковГУ
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ПсковГУ

Yeast Translational Activator Mss51p and Human ZMYND17 – Two Proteins with a Common Origin, but Different Functionsстатья Исследовательская статья

Прикрепленные файлы