Interaction of the Microbiota With the Host's Gastro-Intestinal, Nervous and Immune System in Terms of Network Organization

Oleskin, A.V.; Shenderov, B.A.

Авторы: Oleskin A.V., Shenderov B.A.
Сборник: Reference Module in Food Science
Год издания: 2021
Издательство: ELSEVIER INC
Местоположение издательства: 525 B STREET, STE 1900, SAN DIEGO, USA, CA,92101-4495
Первая страница: 1
Последняя страница: 16
DOI: 10.1016/b978-0-12-819265-8.00053-x
Аннотация: The symbiotic microbiota of the human gut constantly interacts with host (eukaryotic) cells, both under normal and pathological conditions. This ongoing interaction depends on a wide spectrum of signal molecules, including a large number of neuro- and immunochemicals. The whole pattern of interactivity is based on a complex distributed decentralized network structure involving (i) microbial cells; (ii) gut mucosal cells; (iii) neurons and glial cells of the enteric nervous system (ENS); (iv) immune cells of the gut-associated lymphoid tissue (GALT). Of paramount importance for the physical and mental health state of the host organism is the dialog between microbial cells and nerve cells that connect to the central and peripheral nervous system via microbially produced neurochemicals, notably biogenic amines, amino acids, peptides, SCFAs, and gasotransmitters, as well as, more directly, via the afferent fibers of the vagal nerve. A special section concentrates on the interaction of the microbiota with the immune system, which has been shown to strongly influence the development and maturation of the innate and adaptive immune system. This review also emphasizes the implications of research on the human microbiota for health care and biotechnology, including the idea of developing microbial cultures-based biofactories of biologically active substances exemplified by neurochemicals.
Добавил в систему: Олескин Александр Владимирович

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Interaction of the Microbiota With the Host's Gastro-Intestinal, Nervous and Immune System in Terms of Network Organizationстатья

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