Аннотация:Socio-economic transformations of living conditions of the population of Russia led to a change in the adolescents health indicators. There was an increase in the incidence of diseases determined by environmental quality. This article is analyzed the regional characteristics of the adolescent health status of Smolensk region (western part of Russia), including an analysis of the current adolescent health status by incidence rates. Materials and methods of the research. The study is based on age-standardized incidence rates (age-standardized to the 2000 Russian population) among adolescents in Smolensk region between 1999–2016 years. For analysis, we took the indicators of the general incidence of adolescents in the most significant classes of diseases. We analyzed data using two algorithms – typological algorithm and integral ranking calculations. The results of the study and their discussion. As a result of mathematical cartographic modeling, clusters were obtained that give an objective idea of adolescent health status. Integral ranking calculations determine districts with negative trends in health indicators associated with the environment. The use of multidimensional classifications allows, avoiding subjectivity in assessments, to analyze long-term data. Conclusions. The use of multidimensional classifications allows, avoiding subjectivity in assessments, to analyze long-term data. Cartographic visualization based on mathematical modeling makes it possible to effectively interpret the situation, opens up mechanisms for practical application in managerial decision making in the healthcare sector. The results will be transferred to the Department of Health of the Smolensk region. Negative trends in changes in health indicators of adolescents associated with the state of the environment indicate an increase in environmental risks for the population of the Smolensk region.