Targeting inflammation and oxidative stress as a therapy for ischemic kidney injuryстатьяПеревод
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Дата последнего поиска статьи во внешних источниках: 1 февраля 2021 г.
Аннотация:Inflammation and oxidative stress are the main pathological processes that accompany ischemic injury of the kidneys and other organs. Based on this, these factors are often chosen as a target for the treatment of acute renal injury in a variety of experimental and clinical studies. Note, that since these two components are closely interrelated during AKI development, substances that treat one of the processes often affect the other. The review considers several groups of promising nephroprotectors that have both anti-inflammatory and antioxidant effects. For example, many antioxidants, such as vitamins, polyphenolic compounds, and mitochondria-targeted antioxidants, not only reduce the production of reactive oxygen species in the cell but also modulate the activity of the immune cells. On the other hand, immunosuppressors and non-steroidal anti-inflammatory drugs that primarily affect inflammation also reduce oxidative stress under some conditions. One more group is represented by hormones, in particular estrogens and melatonin, which significantly reduce the severity of kidney damage through modulation of both these processes. We conclude that drugs with combined anti-inflammatory and antioxidant capacities are the most promising agents for the treatment of acute ischemic kidney injury.